Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia

Cytotoxic T-lymphocyte (CTL)-mediated platelet destruction and aberrant cytokine profiles play important roles in the pathogenesis of primary immune thrombocytopenia (ITP). Interleukin-27 (IL-27) has pleiotropic immunomodulatory effects. However, the effect of IL-27 on CTL activity in ITP has not be...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Zhou, Hai, Qiu, Ji-hua, Wang, Tong, Yu, Ying-yi, Liu, Xue-na, Li, Xin, Wang, Ya-wen, Hou, Yu, Li, Li-zhen, Liu, Xin-guang, Hou, Ming, Peng, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239337/
https://ncbi.nlm.nih.gov/pubmed/25298039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-580084
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