Complete biosynthesis of a sulfated chondroitin in Escherichia coli

Sulfated glycosaminoglycans (GAGs) are a class of important biologics that are currently manufactured by extraction from animal tissues. Although such methods are unsustainable and prone to contamination, animal-free production methods have not emerged as competitive alternatives due to complexities...

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Udgivet i:Nat Commun
Main Authors: Badri, Abinaya, Williams, Asher, Awofiranye, Adeola, Datta, Payel, Xia, Ke, He, Wenqin, Fraser, Keith, Dordick, Jonathan S., Linhardt, Robert J., Koffas, Mattheos A. G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925653/
https://ncbi.nlm.nih.gov/pubmed/33654100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21692-5
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