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N-glycolyl chondroitin synthesis using metabolically engineered E. coli

N-glycolyl chondroitin (Gc-CN) is a metabolite of N-glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat. Neu5Gc cannot be biosynthesized by humans due to an evolutionary mut...

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Détails bibliographiques
Publié dans:AMB Express
Auteurs principaux: Awofiranye, Adeola E., Baytas, Sultan N., Xia, Ke, Badri, Abinaya, He, Wenqin, Varki, Ajit, Koffas, Mattheos, Linhardt, Robert J.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429809/
https://ncbi.nlm.nih.gov/pubmed/32803432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13568-020-01084-6
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