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N-glycolyl chondroitin synthesis using metabolically engineered E. coli

N-glycolyl chondroitin (Gc-CN) is a metabolite of N-glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat. Neu5Gc cannot be biosynthesized by humans due to an evolutionary mut...

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發表在:AMB Express
Main Authors: Awofiranye, Adeola E., Baytas, Sultan N., Xia, Ke, Badri, Abinaya, He, Wenqin, Varki, Ajit, Koffas, Mattheos, Linhardt, Robert J.
格式: Artigo
語言:Inglês
出版: Springer Berlin Heidelberg 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429809/
https://ncbi.nlm.nih.gov/pubmed/32803432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13568-020-01084-6
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