N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils

Biosynthesis of the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) was lost during human evolution due to inactivation of the CMAH gene, possibly expediting divergence of the Homo lineage, due to a partial fertility barrier. Neu5Gc catabolism generates N-glycolylhexosamines, which a...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bergfeld, Anne K., Lawrence, Roger, Diaz, Sandra L., Pearce, Oliver M. T., Ghaderi, Darius, Gagneux, Pascal, Leakey, Meave G., Varki, Ajit
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625913/
https://ncbi.nlm.nih.gov/pubmed/28893995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706306114
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