Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INCORPORATION OF N-GLYCOLYLHEXOSAMINES INTO MAMMALIAN GLYCANS BY FEEDING N-GLYCOLYLGALACTOSAMINE

The outermost positions of mammalian cell-surface glycans are predominantly occupied by the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). To date, hydroxylation of CMP-Neu5Ac resulting in the conversion into CMP-Neu5Gc is the only known enzymatic reaction in m...

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Detalhes bibliográficos
Main Authors: Bergfeld, Anne K., Pearce, Oliver M. T., Diaz, Sandra L., Lawrence, Roger, Vocadlo, David J., Choudhury, Biswa, Esko, Jeffrey D., Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436526/
https://ncbi.nlm.nih.gov/pubmed/22692203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.363499
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