Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease

BACKGROUND: Opening of the blood-brain barrier (BBB) induced with MRI-guided focused ultrasound has been shown in experimental animal models to reduce amyloid-β plaque burden, improve memory performance, and facilitate delivery of therapeutic agents to the brain. However, physiologic effects of this...

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Detalhes bibliográficos
Publicado no:Radiology
Main Authors: Mehta, Rashi I., Carpenter, Jeffrey S., Mehta, Rupal I., Haut, Marc W., Ranjan, Manish, Najib, Umer, Lockman, Paul, Wang, Peng, D’haese, Pierre-François, Rezai, Ali R.
Formato: Artigo
Idioma:Inglês
Publicado em: Radiological Society of North America 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924515/
https://ncbi.nlm.nih.gov/pubmed/33399511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1148/radiol.2021200643
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