β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease

The blood–brain barrier (BBB) limits therapeutic delivery in Alzheimer’s disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening and reduction in β-amyloid plaque with focused ultrasound (FUS). We recently demonstrated the feasibility, safety, and reversibilit...

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Autori principali: Pierre-François D’Haese, Manish Ranjan, Alexander Song, Marc W. Haut, Jeffrey Carpenter, Gerard Dieb, Umer Najib, Peng Wang, Rashi I. Mehta, J. Levi Chazen, Sally Hodder, Daniel Claassen, Michael Kaplitt, Ali R. Rezai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-10-01
Serie:Frontiers in Human Neuroscience
Soggetti:
Alzheimer’s disease
focused ultrasound
FUS
β-amyloid reduction
hippocampus
blood-brain barrier
Accesso online:https://www.frontiersin.org/article/10.3389/fnhum.2020.593672/full
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