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Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids
PQLC2, a lysosomal cationic amino acid transporter, also serves as a sensor that responds to scarcity of its substrates by recruiting a protein complex composed of C9orf72, SMCR8, and WDR41 to the surface of lysosomes. This protein complex controls multiple aspects of lysosome function. Although it...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7923529/ https://ncbi.nlm.nih.gov/pubmed/33597295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014941118 |
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