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Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

PQLC2, a lysosomal cationic amino acid transporter, also serves as a sensor that responds to scarcity of its substrates by recruiting a protein complex composed of C9orf72, SMCR8, and WDR41 to the surface of lysosomes. This protein complex controls multiple aspects of lysosome function. Although it...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Talaia, Gabriel, Amick, Joseph, Ferguson, Shawn M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923529/
https://ncbi.nlm.nih.gov/pubmed/33597295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014941118
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