Selenomethionine as an expressible handle for bioconjugations

Site-selective chemical bioconjugation reactions are enabling tools for the chemical biologist. Guided by a careful study of the selenomethionine (SeM) benzylation, we have refined the reaction to meet the requirements of practical protein bioconjugation. SeM is readily introduced through auxotrophi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Flood, Dillon T., Hintzen, Jordi C. J., Knouse, Kyle W., Hill, David E., Lu, Chenxi, Cistrone, Philip A., Chen, Jason S., Otomo, Takanori, Dawson, Philip. E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923357/
https://ncbi.nlm.nih.gov/pubmed/33602807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005164118
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