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Leveraging the Knorr Pyrazole Synthesis for the Facile Generation of Thioester Surrogates for use in NCL

Facile synthesis of C-terminal thioesters is integral to native chemical ligation (NCL) strategies for chemical protein synthesis. Here we introduce a new method of mild peptide activation, which leverages SPPS on an established resin linker and a classical heterocyclic chemistry to convert C-termin...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Flood, Dillon T., Hintzen, Jordi C. J., Bird, Michael J., Cistrone, Philip A., Chen, Jason S., Dawson, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126375/
https://ncbi.nlm.nih.gov/pubmed/29908104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201805191
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