Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer’s pathology

Synaptic failure underlies cognitive impairment in Alzheimer’s disease (AD). Cumulative evidence suggests a strong link between mitochondrial dysfunction and synaptic deficits in AD. We previously found that oligomycin-sensitivity conferring protein (OSCP) dysfunction produces pronounced neuronal mi...

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Vydáno v:Neurobiol Aging
Hlavní autoři: Gauba, Esha, Sui, Shaomei, Tian, Jing, Driskill, Christopher, Jia, Kun, Yu, Chunxiao, Rughwani, Tripta, Wang, Qi, Kroener, Sven, Guo, Lan, Du, Heng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923248/
https://ncbi.nlm.nih.gov/pubmed/33254080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.09.018
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