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Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo

SIMPLE SUMMARY: The etiologic role of biliary reflux in hypopharyngeal cancer is supported by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at weakly acidic pH (5.5–6.0). The carcinogenic effect of bile at strongly acidic pH (pH 3.0) was recently documented in v...

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Foilsithe in:Cancers (Basel)
Main Authors: Sasaki, Clarence T., Doukas, Sotirios G., Doukas, Panagiotis G., Vageli, Dimitra P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923205/
https://ncbi.nlm.nih.gov/pubmed/33670587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13040852
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