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The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model

Supraesophageal bile reflux at strongly acidic pH can cause hypopharyngeal squamous cell cancer, through activation of the oncogenic NF-κB-related pathway. We hypothesize that topical pre- or post-application of pharmacologic NF-κB inhibitor, BAY 11-7082 (0.25 μmol), on murine (C57BL/6J) HM (twice a...

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發表在:Oncotarget
Main Authors: Vageli, Dimitra P., Kasle, David, Doukas, Sotirios G., Doukas, Panagiotis G., Sasaki, Clarence T.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476734/
https://ncbi.nlm.nih.gov/pubmed/32934775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27706
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