Oligomeric Aβ(1-42) Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

Alzheimer’s disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration (AMD) patients. To study Aβ-induced retinopathy, wild-type mice were injected with nanomolar human oligomeric Aβ(1-42), which recapitulate the...

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Publicado no:Cells
Main Authors: Lynn, Savannah A., Johnston, David A., Scott, Jenny A., Munday, Rosie, Desai, Roshni S., Keeling, Eloise, Weaterton, Ruaridh, Simpson, Alexander, Davis, Dillon, Freeman, Thomas, Chatelet, David S., Page, Anton, Cree, Angela J., Lee, Helena, Newman, Tracey A., Lotery, Andrew J., Ratnayaka, J. Arjuna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922851/
https://ncbi.nlm.nih.gov/pubmed/33671133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10020413
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