An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy

Impaired cargo trafficking and the aggregation of intracellular macromolecules are key features of neurodegeneration, and a hallmark of aged as well as diseased retinal pigment epithelial (RPE) cells in the eye. Here, photoreceptor outer segments (POS), which are internalized daily by RPE cells, wer...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Principais autores: Keeling, Eloise, Culling, Annabelle J., Johnston, David A., Chatelet, David S., Page, Anton, Tumbarello, David A., Lotery, Andrew J., Ratnayaka, J. Arjuna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555953/
https://ncbi.nlm.nih.gov/pubmed/32932802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186647
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