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De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans

Defects in the mitochondrial genome (mitochondrial DNA (mtDNA)) are associated with both congenital and acquired disorders in humans. Nuclear-encoded DNA polymerase subunit gamma (POLG) plays an important role in mtDNA replication, and proofreading and mutations in POLG have been linked with increas...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Genes (Basel)
Main Authors: Lee, Yeonmi, Kim, Taeho, Lee, Miju, So, Seongjun, Karagozlu, Mustafa Zafer, Seo, Go Hun, Choi, In Hee, Lee, Peter C. W., Kim, Chong-Jai, Kang, Eunju, Lee, Beom Hee
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2021
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922481/
https://ncbi.nlm.nih.gov/pubmed/33671400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes12020284
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