Chemogenetic ON and OFF switches for RNA virus replication

Therapeutic application of RNA viruses as oncolytic agents or gene vectors requires a tight control of virus activity if toxicity is a concern. Here we present a regulator switch for RNA viruses using a conditional protease approach, in which the function of at least one viral protein essential for...

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Publicado no:Nat Commun
Main Authors: Heilmann, E., Kimpel, J., Hofer, B., Rössler, A., Blaas, I., Egerer, L., Nolden, T., Urbiola, C., Kräusslich, H. G., Wollmann, G., von Laer, D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921684/
https://ncbi.nlm.nih.gov/pubmed/33649317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21630-5
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