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Switch from translation to RNA replication in a positive-stranded RNA virus

In positive-stranded viruses, the genomic RNA serves as a template for both translation and RNA replication. Using poliovirus as a model, we examined the interaction between these two processes. We show that the RNA polymerase is unable to replicate RNA templates undergoing translation. We discovere...

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Autors principals: Gamarnik, Andrea V., Andino, Raul
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC317040/
https://ncbi.nlm.nih.gov/pubmed/9694795
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