Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy

In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms to preserve their quiescence and genome integrity. DNA-damaging stress can perturb HSC homeostasis by affecting their survival, self-renewal, and differentiation. Ablation of the ki...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Fortin, Jerome, Bassi, Christian, Ramachandran, Parameswaran, Li, Wanda Y., Tian, Ruxiao, Zarrabi, Ida, Hill, Graham, Snow, Bryan E., Haight, Jillian, Tobin, Chantal, Hodgson, Kelsey, Wakeham, Andrew, Stambolic, Vuk, Mak, Tak W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919727/
https://ncbi.nlm.nih.gov/pubmed/33444287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131698
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