Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs

CRISPR-Cas9 deletion (CRISPR-del) is the leading approach for eliminating DNA from mammalian cells and underpins a variety of genome-editing applications. Target DNA, defined by a pair of double-strand breaks (DSBs), is removed during nonhomologous end-joining (NHEJ). However, the low efficiency of...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Bosch-Guiteras, Núria, Uroda, Tina, Guillen-Ramirez, Hugo A., Riedo, Rahel, Gazdhar, Amiq, Esposito, Roberta, Pulido-Quetglas, Carlos, Zimmer, Yitzhak, Medová, Michaela, Johnson, Rory
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919447/
https://ncbi.nlm.nih.gov/pubmed/33574136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.265736.120
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