Učitavanje...
Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs
CRISPR-Cas9 deletion (CRISPR-del) is the leading approach for eliminating DNA from mammalian cells and underpins a variety of genome-editing applications. Target DNA, defined by a pair of double-strand breaks (DSBs), is removed during nonhomologous end-joining (NHEJ). However, the low efficiency of...
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| Izdano u: | Genome Res |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7919447/ https://ncbi.nlm.nih.gov/pubmed/33574136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.265736.120 |
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