Innate immunity protein IFITM3 modulates γ-secretase in Alzheimer disease

Innate immunity is associated with Alzheimer disease (AD)(1), however, the influence of immune activation on Aβ production is unknown(2,3). Here, we identify interferon-induced transmembrane protein 3 (IFITM3) as a γ-secretase modulatory protein, establishing a mechanism by which inflammation impact...

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Publicado no:Nature
Main Authors: Hur, Ji-Yeun, Frost, Georgia R., Wu, Xianzhong, Crump, Christina, Pan, Si Jia, Wong, Eitan, Barros, Marilia, Li, Thomas, Nie, Pengju, Zhai, Yujia, Wang, Jen Chyong, TCW, Julia, Guo, Lei, McKenzie, Andrew, Ming, Chen, Zhou, Xianxiao, Wang, Minghui, Sagi, Yotam, Renton, Alan E., Esposito, Bianca T., Kim, Yong, Sadleir, Katherine R., Trinh, Ivy, Rissman, Robert A., Vassar, Robert, Zhang, Bin, Johnson, Douglas S., Masliah, Eliezer, Greengard, Paul, Goate, Alison, Li, Yue-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919141/
https://ncbi.nlm.nih.gov/pubmed/32879487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2681-2
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