The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

BACKGROUND: In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte anabolism...

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Pubblicato in:BMC Musculoskelet Disord
Autori principali: Tanaka, Nobuho, Tsuno, Hirotaka, Ohashi, Satoru, Iwasawa, Mitsuyasu, Furukawa, Hiroshi, Kato, Tomohiro, Fukui, Naoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916266/
https://ncbi.nlm.nih.gov/pubmed/33639898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-04096-w
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