The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

BACKGROUND: In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte anabolism...

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Publicat a:BMC Musculoskelet Disord
Autors principals: Tanaka, Nobuho, Tsuno, Hirotaka, Ohashi, Satoru, Iwasawa, Mitsuyasu, Furukawa, Hiroshi, Kato, Tomohiro, Fukui, Naoshi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916266/
https://ncbi.nlm.nih.gov/pubmed/33639898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-04096-w
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