The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

BACKGROUND: In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte anabolism...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Musculoskelet Disord
Prif Awduron: Tanaka, Nobuho, Tsuno, Hirotaka, Ohashi, Satoru, Iwasawa, Mitsuyasu, Furukawa, Hiroshi, Kato, Tomohiro, Fukui, Naoshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916266/
https://ncbi.nlm.nih.gov/pubmed/33639898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-04096-w
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