The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

BACKGROUND: In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte anabolism...

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Veröffentlicht in:BMC Musculoskelet Disord
Hauptverfasser: Tanaka, Nobuho, Tsuno, Hirotaka, Ohashi, Satoru, Iwasawa, Mitsuyasu, Furukawa, Hiroshi, Kato, Tomohiro, Fukui, Naoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916266/
https://ncbi.nlm.nih.gov/pubmed/33639898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-04096-w
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