Small-molecule inhibitors of histone deacetylase improve CRISPR-based adenine base editing

CRISPR-based base editors (BEs) are widely used to induce nucleotide substitutions in living cells and organisms without causing the damaging DNA double-strand breaks and DNA donor templates. Cytosine BEs that induce C:G to T:A conversion and adenine BEs that induce A:T to G:C conversion have been d...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Shin, Ha Rim, See, Ji-Eun, Kweon, Jiyeon, Kim, Heon Seok, Sung, Gi-Jun, Park, Sojung, Jang, An-Hee, Jang, Gayoung, Choi, Kyung‐Chul, Kim, Inki, Kim, Jin-Soo, Kim, Yongsub
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Synthetic Biology and Bioengineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913676/
https://ncbi.nlm.nih.gov/pubmed/33544854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab052
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