A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determinat...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Kweon, Jiyeon, Jang, An-Hee, Shin, Ha Rim, See, Ji-Eun, Lee, Woochang, Lee, Jong Won, Chang, Suhwan, Kim, Kyunggon, Kim, Yongsub
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937211/
https://ncbi.nlm.nih.gov/pubmed/31467430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0968-2
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