A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determinat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogene
Prif Awduron: Kweon, Jiyeon, Jang, An-Hee, Shin, Ha Rim, See, Ji-Eun, Lee, Woochang, Lee, Jong Won, Chang, Suhwan, Kim, Kyunggon, Kim, Yongsub
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Brief Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937211/
https://ncbi.nlm.nih.gov/pubmed/31467430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0968-2
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg