Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions in the residue at position 4 (p4) binding to TCR. The effec...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Cavalluzzo, Beatrice, Ragone, Concetta, Mauriello, Angela, Petrizzo, Annacarmen, Manolio, Carmen, Caporale, Andrea, Vitagliano, Luigi, Ruvo, Menotti, Buonaguro, Luigi, Tagliamonte, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913412/
https://ncbi.nlm.nih.gov/pubmed/33637105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02757-x
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