Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions in the residue at position 4 (p4) binding to TCR. The effec...

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Библиографические подробности
Опубликовано в: :J Transl Med
Главные авторы: Cavalluzzo, Beatrice, Ragone, Concetta, Mauriello, Angela, Petrizzo, Annacarmen, Manolio, Carmen, Caporale, Andrea, Vitagliano, Luigi, Ruvo, Menotti, Buonaguro, Luigi, Tagliamonte, Maria
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913412/
https://ncbi.nlm.nih.gov/pubmed/33637105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02757-x
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