A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

Bulky DNA lesions in transcribed strands block RNA polymerase II (RNAPII) elongation and induce a genome-wide transcriptional arrest. The transcription-coupled repair (TCR) pathway efficiently removes transcription-blocking DNA lesions, but how transcription is restored in the genome following DNA r...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: van den Heuvel, Diana, Spruijt, Cornelia G., González-Prieto, Román, Kragten, Angela, Paulsen, Michelle T., Zhou, Di, Wu, Haoyu, Apelt, Katja, van der Weegen, Yana, Yang, Kevin, Dijk, Madelon, Daxinger, Lucia, Marteijn, Jurgen A., Vertegaal, Alfred C. O., Ljungman, Mats, Vermeulen, Michiel, Luijsterburg, Martijn S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910549/
https://ncbi.nlm.nih.gov/pubmed/33637760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21520-w
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