Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats

Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies. However, the quality of PSCs, and donor-host cell competition in chimeras often present s...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kobayashi, Toshihiro, Goto, Teppei, Oikawa, Mami, Sanbo, Makoto, Yoshida, Fumika, Terada, Reiko, Niizeki, Naoko, Kajitani, Naoyo, Kazuki, Kanako, Kazuki, Yasuhiro, Hochi, Shinichi, Nakauchi, Hiromitsu, Surani, M. Azim, Hirabayashi, Masumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910474/
https://ncbi.nlm.nih.gov/pubmed/33637711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21557-x
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