Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats

Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies. However, the quality of PSCs, and donor-host cell competition in chimeras often present s...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kobayashi, Toshihiro, Goto, Teppei, Oikawa, Mami, Sanbo, Makoto, Yoshida, Fumika, Terada, Reiko, Niizeki, Naoko, Kajitani, Naoyo, Kazuki, Kanako, Kazuki, Yasuhiro, Hochi, Shinichi, Nakauchi, Hiromitsu, Surani, M. Azim, Hirabayashi, Masumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910474/
https://ncbi.nlm.nih.gov/pubmed/33637711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21557-x
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