Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

The innate immune response influences neural repair after spinal cord injury (SCI). Here, we combined myeloid-specific transcriptomics and single-cell RNA sequencing to uncover not only a common core but also temporally distinct gene programs in injury-activated microglia and macrophages (IAM). Intr...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Wahane, Shalaka, Zhou, Xianxiao, Zhou, Xiang, Guo, Lei, Friedl, Marie-Sophie, Kluge, Michael, Ramakrishnan, Aarthi, Shen, Li, Friedel, Caroline C., Zhang, Bin, Friedel, Roland H., Zou, Hongyan
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909890/
https://ncbi.nlm.nih.gov/pubmed/33637528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd8811
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