Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

The innate immune response influences neural repair after spinal cord injury (SCI). Here, we combined myeloid-specific transcriptomics and single-cell RNA sequencing to uncover not only a common core but also temporally distinct gene programs in injury-activated microglia and macrophages (IAM). Intr...

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Vydáno v:Sci Adv
Hlavní autoři: Wahane, Shalaka, Zhou, Xianxiao, Zhou, Xiang, Guo, Lei, Friedl, Marie-Sophie, Kluge, Michael, Ramakrishnan, Aarthi, Shen, Li, Friedel, Caroline C., Zhang, Bin, Friedel, Roland H., Zou, Hongyan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909890/
https://ncbi.nlm.nih.gov/pubmed/33637528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd8811
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