Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

The innate immune response influences neural repair after spinal cord injury (SCI). Here, we combined myeloid-specific transcriptomics and single-cell RNA sequencing to uncover not only a common core but also temporally distinct gene programs in injury-activated microglia and macrophages (IAM). Intr...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Wahane, Shalaka, Zhou, Xianxiao, Zhou, Xiang, Guo, Lei, Friedl, Marie-Sophie, Kluge, Michael, Ramakrishnan, Aarthi, Shen, Li, Friedel, Caroline C., Zhang, Bin, Friedel, Roland H., Zou, Hongyan
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909890/
https://ncbi.nlm.nih.gov/pubmed/33637528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd8811
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