Subchronic N-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice

The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and N-methyl-d-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders and neurodegenerative diseases and may be related to cognitive impairments. Recently, we showed that N-acetylcy...

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Pubblicato in:Antioxidants (Basel)
Autori principali: Blanco Ayala, Tonali, Ramírez Ortega, Daniela, Ovalle Rodríguez, Paulina, Pineda, Benjamín, Pérez de la Cruz, Gonzalo, González Esquivel, Dinora, Schwarcz, Robert, Sathyasaikumar, Korrapati V., Jiménez Anguiano, Anabel, Pérez de la Cruz, Verónica
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909398/
https://ncbi.nlm.nih.gov/pubmed/33498402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10020147
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