Subchronic N-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice

The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and N-methyl-d-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders and neurodegenerative diseases and may be related to cognitive impairments. Recently, we showed that N-acetylcy...

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Publicado en:Antioxidants (Basel)
Autores principales: Blanco Ayala, Tonali, Ramírez Ortega, Daniela, Ovalle Rodríguez, Paulina, Pineda, Benjamín, Pérez de la Cruz, Gonzalo, González Esquivel, Dinora, Schwarcz, Robert, Sathyasaikumar, Korrapati V., Jiménez Anguiano, Anabel, Pérez de la Cruz, Verónica
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909398/
https://ncbi.nlm.nih.gov/pubmed/33498402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10020147
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