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Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death
Progressive degeneration of dopaminergic neurons characterizes Parkinson’s disease (PD). This neuronal loss occurs through diverse mechanisms, including a form of programmed cell death dependent on poly-(ADP-ribose) polymerase-1 (PARP1) called parthanatos. Deficient activity of the kinase Akt1 and a...
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| Udgivet i: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7909008/ https://ncbi.nlm.nih.gov/pubmed/33443209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax7119 |
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