Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection

Progressive dopaminergic neurodegeneration is responsible for the canonical motor deficits in Parkinson's disease (PD). The widely prescribed anti-diabetic medicine metformin is effective in preventing neurodegeneration in animal models; however, despite the significant potential of metformin f...

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Опубликовано в: :Oncotarget
Главные авторы: Kang, Hojin, Khang, Rin, Ham, Sangwoo, Jeong, Ga Ram, Kim, Hyojung, Jo, Minkyung, Lee, Byoung Dae, Lee, Yun Il, Jo, Areum, Park, ChiHu, Kim, Hyein, Seo, Jeongkon, Paek, Sun Ha, Lee, Yun-Song, Choi, Jeong-Yun, Lee, Yunjong, Shin, Joo-Ho
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
Предметы:
Research Paper: Gerotarget (Focus on Aging)
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564711/
https://ncbi.nlm.nih.gov/pubmed/28611284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18122
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