Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients

In Feb 2020, we developed a physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine (HCQ) and integrated in vitro anti-viral effect to support dosing design of HCQ in the treatment of COVID-19 patients in China. This, along with emerging research and clinical findings, supported bro...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Zhang, Miao, Yao, Xueting, Hou, Zhe, Guo, Xuan, Tu, Siqi, Lei, Zihan, Yu, Zhiheng, Liu, Xuanlin, Cui, Cheng, Chen, Xijing, Shen, Ning, Song, Chunli, Qiao, Jie, Xiang, Xiaoqiang, Li, Haiyan, Liu, Dongyang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907647/
https://ncbi.nlm.nih.gov/pubmed/33643034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.585021
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