Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model

Chloroquine (CQ) and hydroxychloroquine (HCQ) have been challenged in treating COVID-19 patients and still under debate due to the uncertainty regarding the effectiveness and safety, and there is still lack of the systematic study on the toxicity of these two drugs. To further uncover the toxicity p...

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Vydáno v:Front Pharmacol
Hlavní autoři: Yang, Jianling, Guo, Zhengyang, Liu, Xu, Liu, Qi, Wu, Meng, Yao, Xueting, Liu, Yang, Cui, Cheng, Li, Haiyan, Song, Chunli, Liu, Dongyang, Xue, Lixiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919379/
https://ncbi.nlm.nih.gov/pubmed/33658924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.574720
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