Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model

Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution of CQ and apply it to optimize dosage regimens, a PBPK model, with para...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Cui, Cheng, Zhang, Miao, Yao, Xueting, Tu, Siqi, Hou, Zhe, Jie En, Valerie Sia, Xiang, Xiaoqiang, Lin, Jing, Cai, Ting, Shen, Ning, Song, Chunli, Qiao, Jie, Zhang, Shun, Li, Haiyan, Liu, Dongyang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252145/
https://ncbi.nlm.nih.gov/pubmed/32834950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.04.007
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