Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides

Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective cis-dihydroxylation of carbocyclic rings and format...

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Bibliografiske detaljer
Udgivet i:Front Bioeng Biotechnol
Main Authors: Boyd, Derek R., Sharma, Narain D., Loke, Pui L., Carroll, Jonathan G., Stevenson, Paul J., Hoering, Patrick, Allen, Christopher C. R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Bioengineering and Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907597/
https://ncbi.nlm.nih.gov/pubmed/33644006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.619175
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