Rate-determining Attack on Substrate Precedes Rieske Cluster Oxidation during cis-Dihydroxylation by Benzoate Dioxygenase

Rieske dearomatizing dioxygenases utilize a Rieske iron-sulfur cluster and a mononuclear Fe(II) located 15 Å across a subunit boundary to catalyze O(2)-dependent formation of cis-dihydrodiol products from aromatic substrates. During catalysis, O(2) binds to the Fe(II) while the substrate bind nearby...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Rivard, Brent S., Rogers, Melanie S., Marell, Daniel J., Neibergall, Matthew B., Chakrabarty, Sarmistha, Cramer, Christopher J., Lipscomb, John D.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527349/
https://ncbi.nlm.nih.gov/pubmed/26154836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00573
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