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Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases

The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative diseases caused by the abnormal expansion of a CAG trinucleotide repeat that are translated into an expanded polyQ stretch in the disease-causative proteins. The expanded polyQ stretch itself plays a critical disease-causa...

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Bibliografiska uppgifter
I publikationen:Front Neurosci
Huvudupphovsmän: Minakawa, Eiko N., Nagai, Yoshitaka
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907447/
https://ncbi.nlm.nih.gov/pubmed/33642983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.621996
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