c-Jun Amino Terminal Kinase Signaling Promotes Aristolochic Acid-Induced Acute Kidney Injury

Aristolochic acid (AA) is a toxin that induces DNA damage in tubular epithelial cells of the kidney and is the cause of Balkan Nephropathy and Chinese Herb Nephropathy. In cultured tubular epithelial cells, AA induces a pro-fibrotic response via the c-Jun amino terminal kinase (JNK) signaling pathwa...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Yang, Fan, Ozols, Elyce, Ma, Frank Y., Leong, Khai Gene, Tesch, Greg H., Jiang, Xiaoyun, Nikolic-Paterson, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907440/
https://ncbi.nlm.nih.gov/pubmed/33643061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.599114
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