Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis

Cyclophilins have important homeostatic roles, but following tissue injury, cyclophilin A (CypA) can promote leukocyte recruitment and inflammation, while CypD can facilitate mitochondrial-dependent cell death. This study investigated the therapeutic potential of a selective cyclophilin inhibitor (G...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Leong, Khai Gene, Ozols, Elyce, Kanellis, John, Badal, Shawn S., Liles, John T., Nikolic-Paterson, David J., Ma, Frank Y.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7795230/
https://ncbi.nlm.nih.gov/pubmed/33383945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010271
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