Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding

Beta-2-glycoprotein I (β2GPI) is a blood protein and the major antigen in the autoimmune disorder antiphospholipid syndrome (APS). β2GPI exists mainly in closed or open conformations and comprises of 11 disulfides distributed across five domains. The terminal Cys288/Cys326 disulfide bond at domain V...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Buchholz, Ina, McDonnell, Thomas, Nestler, Peter, Tharad, Sudarat, Kulke, Martin, Radziszewska, Anna, Ripoll, Vera M., Schmidt, Frank, Hammer, Elke, Toca-Herrera, Jose L., Rahman, Anisur, Delcea, Mihaela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907366/
https://ncbi.nlm.nih.gov/pubmed/33633190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84021-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados