Nf1 mutant tumors undergo transcriptome and kinome re-modeling after inhibition of either mTOR or MEK

Loss of the tumor suppressor NF1 leads to activation of RAS effector pathways, which are therapeutically targeted by inhibition of mTOR (mTORi) or MEK (MEKi). However, therapeutic inhibition of RAS effectors leads to the development of drug resistance and ultimately disease progression. To investiga...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Pucciarelli, Daniela, Angus, Steven P., Huang, Benjamin, Zhang, Chi, Nakaoka, Hiroki J., Krishnamurthi, Ganesh, Bandyopadhyay, Sourav, Clapp, D. Wade, Shannon, Kevin, Johnson, Gary L., Nakamura, Jean L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907257/
https://ncbi.nlm.nih.gov/pubmed/32847978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-1017
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