Nf1 mutant tumors undergo transcriptome and kinome re-modeling after inhibition of either mTOR or MEK

Loss of the tumor suppressor NF1 leads to activation of RAS effector pathways, which are therapeutically targeted by inhibition of mTOR (mTORi) or MEK (MEKi). However, therapeutic inhibition of RAS effectors leads to the development of drug resistance and ultimately disease progression. To investiga...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Pucciarelli, Daniela, Angus, Steven P., Huang, Benjamin, Zhang, Chi, Nakaoka, Hiroki J., Krishnamurthi, Ganesh, Bandyopadhyay, Sourav, Clapp, D. Wade, Shannon, Kevin, Johnson, Gary L., Nakamura, Jean L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907257/
https://ncbi.nlm.nih.gov/pubmed/32847978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-1017
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